Angiotensin – Exercise

Angiotensin is something that forms whenever inflammation is present. It is a by-product of metabolism and if left unchecked it can cause huge problems. The main focus in recent years has been to inhibit the formation of Angiotensin by the use of pharmaceutical drugs. However, there is an interesting development that makes use of naturally occurring peptide chains and enzymes to safely inhibit the formation of Angiotensin Converting Enzyme. The small scale evaluations we’ve done so far with a few people with circulatory problems have shown some discernible benefit at the very earliest stage.
If you want to know more about inhibiting ACE and how this all links together with better health please e mail me and i’ll explain

This study came across my desk today and the relevance is obvious.
Acute exercise causes an enhancement of tissue renin–angiotensin system in the kidney in rats
Abstract

Aims: Initially, the renin–angiotensin system (RAS) produced through the classical endocrine pathway was well known for its regulation of blood pressure. However, it was revealed that a local autocrine and/or paracrine RAS may exist in a number of tissues (such as kidney). Exercise causes a redistribution of tissue blood flow, by which the blood flow is greatly increased in active muscles, whereas it is decreased in the splanchnic circulation (such as in the kidney). We hypothesized that exercise causes an enhancement of tissue RAS in the kidney.

Methods: We studied whether exercise affects expression of angiotensinogen and angiotensin-converting enzyme (ACE) and tissue angiotensin II level in the kidney. The rats performed treadmill running for 30-min. Immediately after this exercise, kidney was quickly removed. Control rats remained at rest during this 30-min period.

Results: The expression of angiotensinogen mRNA in the kidney was markedly higher in the exercise rats than in the control rats. ACE mRNA in the kidney was significantly higher in the exercise rats than in the control rats. Western blot analysis confirmed significant upregulation of ACE protein in the kidney after exercise. Tissue angiotensin II level was also increased by exercise.

Conclusion: The present study suggests that the exercise-induced enhancement of tissue RAS in the kidney causes vasoconstriction and hence decreases blood flow in the kidney, which are helpful in increasing blood flow in active muscles, thereby contributing to the redistribution of blood flow during exercise.

http://www3.interscience.wiley.com/journal/118680113/abstract?CRETRY=1&SRETRY=0

1 Center for Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Tsukuba, Ibaraki, Japan

2 Institute of Health and Sport Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan

3 Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan

Correspondence to S. Maeda PhD, Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba, Ibaraki 305-8577, Japan.

E-mail: smaeda@tara.tsukuba.ac.jp

Copyright 2005 Scandinavian Physiological Society

KEYWORDS

angiotensin converting enzyme • angiotensin II • angiotensinogen • redistribution of blood flow