Pregnenolone

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Pregnenolone fights fatigue, boosts memory and more

Pregnenolone is made in the adrenal glands as well as in the liver, ovaries and testicles. It can also be made in the brain and is involved in a variety of brain functions such as memory, concentration and mood.

The body can change pregnenolone into the hormones DHEA or progesterone depending on its needs at a given time. Either of these hormones can be then produce androstenedione, the direct precursor to the other sex hormones including testosterone and the other androgens, and estradiol and the other estrogens. Progesterone can also make cortisol, the stress hormone, and aldosterone, the regulator of blood pressure. This process by which other hormones are made from pregnenolone which is made directly from cholesterol is often referred to as the hormonal cascade.

Clearly, prenenolone is an essential hormone. In the young, prenenolone production averages about 14 mg per day. As the body ages, production declines until at age 75 the body produces about 40% of the amount produced at age 35. As this supply declines, the amount available to make other hormones also decreases.

Although several studies have found that oral pregnenolone reduces fatigue and increases endurance, its claim to fame is its memory enhancement. It accomplishes this by preventing the brain’s neurotransmission system from deteriorating and promoting the release of the neurotransmitter acetycholine. Pregnenolone promotes greater growth of brain cells. The greater the number of brain cells, the greater the ability to retain memories.

Pregnenolone is available without a prescription in creams, capsules and sublingual drops. The usual dosage is 50 to 100 mg. Absorption is best if it is taken with fat.